She was born in 1896 to the architect Fritz Stehlin and Helene von Bavier. She studied sculpture in Munich and was taught by Antoine Bourdelle in Paris. In 1921 she married Emanuel Hoffmann, with whom she first lived in Paris and from 1925 in Brussels. In Paris, but also in Brussels, the two became part of the artistic community and bought paintings from Max Ernst, Paul Klee and Marc Chagall amongst others. In 1930 the family moved to Basel where Emanuel Hoffmann became the vice director of the family ownedHoffmann-La Roche. In Basel, the two became influential figures of the local cultural life. Her husband Emanuel died in 1932 in a serious car accident following which Maja Hoffmann founded the Emanuel Hoffmann Foundation in 1933. The Foundation was established to support the contemporary arts and their artists.