Maine State Route 22
Image:Route [22 westbound, Portland ME.jpg|thumb|First westbound marker for SR 22, near its eastern terminus at Maine [State Route 77|SR 77]]
State Route 22 is a state highway located in southwestern Maine. It serves the western suburbs of Portland, running from Maine State [Route 35|SR 35] in Buxton east into the city, where it ends at SR 77.