MabuterolMabuterol is a selective β2 adrenoreceptor agonist.SynthesisThe halogenation of 2-aniline with iodine and sodium bicarbonate resulted in 2-Amino-5-Iodobenzotrifluoride . Protection with acetic anhydride followed by nucleophilic aromatic displacement with coppercyanide gave N-acetamide . Hydrolysis of the nitrile and the protecting group gave 4-amino-3-benzoic acid . Halogenation with chlorine gave 4-Amino-3-Chloro-5-Benzoic Acid . Halogenation of the acid with thionyl chloride gave 4-Amino-3-chloro-5-benzoylchloride . Treatment with diethyl malonate gave the acetophenone and hence 1-ethanone . Halogenation with bromine in acetic acid led to 1--2-bromoethanone . Treatment with tert-butylamine yielded 1--2-ethenone, . Reduction of the ketone with sodium borohydride completed the synthesis of Mabuterol.