MTO
- Coles County Memorial Airport
- Department of Motor Vehicles
- MTO (video game company)
- Make to order
- Mario Tennis Open
- Mars Telecommunications Orbiter
- Mars transfer orbit
- Marton railway station (Middlesbrough)
- Media Take Out
- Mediterranean Theater of Operations
- Medium-Term budgetary Objective
- Methanol to olefins
- Methylrhenium trioxide
- Ministry of Transportation (Ontario)
- Multimodal transport
- Music Theory Online
- Takeoff (construction)