MPO
- .mpo
- Density matrix renormalization group
- Macedonian Patriotic Organization
- Malaysian Philharmonic Orchestra
- Management and Planning Organization of Iran
- Managerial and Professional Officers
- Mercury Planetary Orbiter
- Metropolitan planning organization
- Mikko Kaasalainen
- Minor Planet Center
- Most Productive Overs method
- Multi-fiber Push-On
- Multiset path ordering
- Myeloperoxidase
- Pocono Mountains Municipal Airport