Matrix metalloproteinase inhibitor
A matrix metalloproteinase inhibitor inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.
The most notorious endogenous metalloproteinases are tissue [inhibitors of metalloproteinases], followed by cartilage-derived [angiogenesis inhibitor]s.
Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs. Examples include:
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria.