MLE
- Competitive programming
- Dosage compensation
- Drosophila
- European law
- Ibrahim Nasir International Airport
- Lee–Enfield
- List of professional designations in the United States
- Major League Eating
- Managed learning environment
- Mars Science Laboratory
- Marxistisk-Leninistisk Enhedsforbund
- Master of European Law
- Maximum likelihood estimation
- Media Lab Europe
- Military Liaison Element
- Mister Leather Europe
- Muconate lactonizing enzyme
- Multi-Lamellar Emulsion
- Multicultural London English
- NBA Salary Cap
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