MLC
- 25 Martin Place
- Legislative Council of the Isle of Man
- MLC Building (disambiguation)
- MLC Limited
- MLC School
- MLC conjecture
- Machine Learning
- Maharashtra Legislative Council
- Major League Cricket
- Marine Logistics Command
- Maritime Labour Convention
- Martin Luther College
- Mauritius Labour Congress
- Meat and Livestock Commission
- Mechanical Licensing Collective
- Megalencephalic leukoencephalopathy with subcortical cysts
- Member of the Legislative Council
- Member of the Legislative Council (India)
- Mercados Libres Campesinos
- Methodist Ladies' College (disambiguation)
- Metropolitan Learning Center (Bloomfield, Connecticut)
- Metropolitan Learning Center (Portland, Oregon)
- Midland Lutheran College
- Midwest Lacrosse Conference
- Military Load Classification
- Minnesota Life College
- Mixed leukocyte culture
- Monarchist League of Canada
- Mono Lake Committee
- Motor landing craft
- Motors Liquidation Company
- Movement for the Liberation of the Congo
- Multi-level cell
- Multileaf collimator
- Myanmar Language Commission
- Myosin light chain