MLA-74

MLA-74, also known as 1-methyllysergic acid ethylamide or as 1-methyl-N-ethyllysergamide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide. It is the 1-methyl derivative of lysergic acid ethylamide. Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivatives, for instance methysergide conversion into methylergometrine, has been observed.

Use and effects

An active dose of MLA-74 in humans is described as being approximately 2mg orally and the drug is said to have about 4 to 5% of the potency of LSD. It is also said to have a faster onset and shorter duration than LSD. For comparison, LAE-32 has a listed dose range of 0.5 to 1.6mg orally, approximately 5 to 10% of the potency of LSD, and is likewise described as faster onset and shorter duration. MLA-74 is about 8-fold less potent than its analogue MLD-41. Both MLA-74 and LAE-32 are described as producing LSD-like psychic effects in humans. However, they are both described as producing only slight or weak hallucinogenic effects.

Pharmacology

Pharamcodynamics

MLA-74 shows about 8.35times the antiserotonergic activity of LSD in the isolated rat uterus in vitro and about 70-fold the activity of LAE-32 in this assay. Unlike LAE-32, MLA-74 is practically devoid of pyretogenic effects in rabbits and is listed as having 0% of the activity of LSD in this regard.

History

MLA-74 was first described in the scientific literature by the late 1950s.