MHC
- Denver, Colorado
- List of mine warfare vessels of the United States Navy
- Maimonides Heritage Center
- Major histocompatibility complex
- Malaysian Hockey Confederation
- Managed health care
- Mars Hill College
- Massachusetts Historical Commission
- Mediterranean Handball Confederation
- Mental health counselor
- Metropolitan Hospital Center
- Mid Hudson Conference
- Mile high club
- Milwaukee Hurling Club
- Mochoʼ language
- Mocopulli Airport
- Model of hierarchical complexity
- Mohawk–Hudson convergence
- Mount Holyoke College
- Murphy-Hoffman Company
- Museum of the History of Catalonia
- Myosin heavy chain
- William E. Macaulay Honors College