MDE
- Athabasca University
- José María Córdova International Airport
- Latitudinal gradients in species diversity
- Major Deegan Expressway
- Major depressive episode
- Markit
- Maryland Department of Education
- Maryland Department of the Environment
- Maximum Downside Exposure
- Methylenedioxyephedrone
- Methylenedioxyethylamphetamine
- Michigan Department of Education
- Microsoft Access
- Microsoft Device Emulator
- Million Dollar Extreme
- Minnesota Department of Education
- Mississippi Department of Education
- Mitsubishi Motors Europe
- Model-driven engineering