MCO
- Coatlán Mixe
- College of Organists
- MC Oran
- MC Oujda
- Malaysian movement control order
- Managed Care Organization
- Manchester Oxford Road railway station
- Manitoba Chamber Orchestra
- Manufacturer’s Certificate of Origin
- Marine Corps Order
- Mars Climate Orbiter
- MegaCon
- Millennial Choirs and Orchestras
- Minecraft
- MinecraftOnline
- Miscellaneous Charges Order
- Modern Chess Openings
- Monaco
- Moody's Corporation
- Moscow Chamber Orchestra
- Motor City Online
- Motorsport Club of Ottawa
- Orlando International Airport