Mitogen-activated protein kinase kinase

Mitogen-activated protein kinase kinase is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase.
MAP2K is classified as.
There are seven genes:

The activators of p38, JNK, and ERK define independent MAP kinase signal transduction pathways. The acronym MEK derives from MAPK/ERK Kinase.

Role in melanoma

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis is induced.