MAP4K1

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1. The protein has been shown to play a role in JNK activation.

Interactions

MAP4K1 has been shown to interact with:

Optimization of inhibitors of MAP4K1 for upregulating the T cell receptor signaling pathway has produced at least one compound that exhibits antitumor activity in an EMT6 syngeneic mouse model, and is an area of ongoing research.