Methoxy arachidonyl fluorophosphonate
Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty [acid amide hydrolase] with special potency, displaying IC50 values in the low-nanomolar range. In addition, it binds to the cannabinoid [receptor type 1|CB1 receptor] in rat brain membrane preparations, but does not appear to agonize or antagonize the receptor, though some related derivatives do show cannabinoid-like properties.