M2613
M2613 is a nonsteroidal estrogen derived from triphenylbromoethylene which was studied for the treatment of breast cancer in women in the 1940s, but was never marketed.
Chemistry
Synthesis
The chemical synthesis of M2613 has been described:The Grignard reaction between 1--2-phenylethanone and 4-Bromoanisole gives 3. Condensation with molecular bromine in the presence of glacial acetic acid completes the synthesis of M2613. Alternately, Grignard reaction between 4-Ethoxy-4'-methoxybenzophenone and benzyl bromide also yields 3.