Lysergine
Lysergine, also known as 9,10-didehydro-6,8β-dimethylergoline, is an ergot alkaloid and serotonin receptor agonist of the ergoline family. It is a minor constituent of ergot.
Pharmacology
Lysergine shows selectivity for activation of the serotonin 5-HT2A receptor over several other closely related serotonin receptors. The drug is a partial agonist of the 5-HT2A receptor with moderate intrinsic activity.An analogue of lysergine, (+)-13-fluorolysergol, is an even more selective agonist of the 5-HT2A receptor than lysergine. However, this compound has relatively weak maximal efficacy in activating the receptor.