Luis Medina

• Luis Medina (designated hitter), American baseball designated hitter and first baseman
• Luis Medina (pitcher), Dominican Republic baseball pitcher
• Luis Medina (athlete), Cuban middle-distance runner
• Luis Medina (swimmer), Bolivian swimmer
• Luis Medina Cantalejo, Spanish football referee
• Luis Caicedo Medina, Ecuadorian footballer
• Luis Manuel Medina, Dominican broadcast journalist