Luis Castillo
Luis Castillo may refer to:
- Luis Castillo (American football), Dominican-American NFL defensive end
- Luis Castillo (second baseman), Dominican Major League Baseball second baseman
- Luis Castillo (pitcher, born 1992), Dominican Major League Baseball pitcher
- Luis Castillo (pitcher, born 1995), Dominican Major League Baseball pitcher
- Luis Castillo (Ecuadorian boxer), boxer from Ecuador
- Luis Castillo (musician), keyboard player and backup vocalist for American rock band P.O.D.
- Luís Leandro Castillo, Argentine footballer
- Luis Castillo (basketball referee), Spanish basketball referee