Rossettini joined Siena in a co-ownership deal on 28 August 2007 for €1.2 million. The deal was made permanent when Siena bought out the contract from Padova in June 2008 for another €1.2 million.
On 12 January 2021 he returned to his first club Padova. On 11 August 2021 he announced his retirement as a player, and was appointed as a U-17 Padova team manager.