Liver X receptor beta

Liver X receptor beta is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the gene.

Function

The liver X receptors were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements characterized by direct repeats separated by 4 nucleotides. Two genes, alpha and beta, are known to encode LXR proteins.

Structure

Crystal structure of human liver X receptor β forming heterodimer with its partner retinoid X receptor α on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element.

Interactions

Liver X receptor beta has been shown to interact with NCOA6 and Retinoid X receptor alpha.