Little Brother
- ARP Little Brother
- Big Brothers Big Sisters of America
- David Mason (writer)
- Franciscan
- International Federation of Little Brothers of the Poor
- King Princess
- Lifeforms (The Future Sound of London album)
- Little Brother (1927 film)
- Little Brother (2014 film)
- Little Brother (2023 film)
- Little Brother (Adventure Time)
- Little Brother (Baillie novel)
- Little Brother (Doctorow novel)
- Little Brother (EP)
- Little Brother (group)
- Little Brother (short story)
- Little Brother Montgomery
- Little Brothers of Francis
- Little Brothers of Jesus
- Little Brothers of Mary
- Little Brothers of St. Francis
- Little Brothers of the Good Shepherd
- Little Brothers of the Gospel
- Little Brothers of the Lamb
- Little Brothers – Friends of the Elderly
- Release (David Knopfler album)
- Sedaka's Back
- The Hurricane (1999 film)
- Yellow House (album)