| Train Name | Railroad | Train Endpoints | Operated |
| TEE Ambrosiano | Ferrovie dello Stato | Milan - Rome | 1974–1987 |
| Bernina Express | RhB | Tirano - St. Moritz - Chur | present |
| Brenner Express | Trenitalia, ÖBB, DB | Florence - Munich
Venice - Munich | present |
| Capri | Trenitalia, ÖBB, DB | Naples - Munich | present |
| Caravaggio | Trenitalia, SNCF | Milan - Turin - Paris | present |
| Casanova | Trenitalia, SŽ | Venice - Ljubljana | 2001–2008 |
| Conca d'Oro | Trenitalia | Milan - Palermo | present |
| Don Giovanni | ČD, ÖBB, Trenitalia | Venice - Vienna - Prague | present |
| Dumas | Trenitalia, SNCF | Milan - Turin - Paris | present |
| EC Borromeo | Cisalpino | Milan - Bern - Basel | present |
| EC Canaletto | Cisalpino | Venice - Zurich | present |
| EC Cinque Terre | Cisalpino | La Spezia - Zurich | present |
| EC Lemano | Cisalpino | Milan - Geneva | present |
| EC Mediolanum | Cisalpino | Milan – Basel | 2004–present |
| EC Monte Rosa | Cisalpino | Milan - Geneva | present |
| EC Verbano | Cisalpino | Milan - Bern - Basel | present |
| EC Vall D’Ossola | Cisalpino | Milan - Bern - Basel | present |
| EC Vallese | Cisalpino | Milan - Geneva | present |
| EN Roma | Trenitalia, SBB-CFF-FFS | Venice - Zurich
Rome - Zurich | present |
| Freccia del Sud | Trenitalia | Milan - Syracuse - Agrigento | present |
| Garda | Trenitalia, ÖBB, DB | Verona - Munich | present |
| Giacomo Puccini | Trenitalia, ÖBB | Ancona - Vienna | present |
| Goldoni | Trenitalia, SŽ, HŽ, MÁV | Venice - Ljubljana - Zagreb - Budapest | present |
| Gottardo | SBB-CFF-FFS, FS/Trenitalia, Cisalpino | Milan - Zurich | 1961–2008 |
| Heidi Express | RhB | Tirano - St. Moritz - Chur | present |
| IC Brianza | Cisalpino | Milan - Bellinzona | present |
| IC Insubria | Trenitalia, SBB-CFF-FFS | Milan - Zurich - Stuttgart | present |
| IC Mediolanum | Trenitalia, SBB-CFF-FFS | Milan - Lucerne - Basel | 2001–2004 |
| IC Monte Ceneri | Trenitalia, SBB-CFF-FFS | Milan - Zurich | present |
| IC Riviera dei Fiori | Trenitalia, SBB-CFF-FFS | Basel - Lucerne - Genoa - Nice | present |
| IC Teodolina | Trenitalia, SBB-CFF-FFS | Milan - Zurich | present |
| IC Ticino | Trenitalia, SBB-CFF-FFS | Milan - Lucerne - Basel | present |
| IC Tiziano | Trenitalia, SBB-CFF-FFS | Milan - Lucerne - Basel | present |
| IC Verdi | Trenitalia, SBB-CFF-FFS | Milan - Lucerne - Basel | present |
| Italicus | Trenitalia | Rome - Munich | discontinued in 1974 after a terrorist attack |
| Johann Strauss | Trenitalia, ÖBB | Venice - Vienna | present |
| Leonardo da Vinci | Trenitalia, ÖBB, DB | Milan - Munich | present |
| Ligure | FS/Trenitalia, SNCF | Milan - Nice – Avignon | 1957–2009 |
| Manzoni | Trenitalia, SNCF | Milan - Turin - Paris | present |
| TEE/IC Mediolanum | FS, ÖBB, DB | Milan – Munich | 1957–1987 |
| Michelangelo | Trenitalia, ÖBB, DB | Rome - Munich | present |
| Montecarlo | Trenitalia, SNCF | Naples - Nice | present |
| Paganini | Trenitalia, ÖBB, DB | Verona - Munich | present |
| Palatino Express | Trenitalia, SNCF | Rome - Florence - Bologna - Paris | Discontinued in December 2011 |
| San Marco | Trenitalia, ÖBB | Venice - Vienna | present |
| Sanremo | Trenitalia, SNCF | Milan - Nice | present |
| Settebello | FS | Milan – Rome | 1953–1984 |
| Stendhal | Trenitalia, SNCF | Venice - Milan - Paris | present |
| Stradivari | Trenitalia, ÖBB | Venice - Vienna | present |
| Tacito | Trenitalia | Terni - Milan | present |
| Tiepolo | Trenitalia, ÖBB, DB | Florence - Munich
Venice - Munich | present |
| Tosca | Trenitalia, ÖBB | Rome - Vienna | present |
| Trenino della neve | RhB | Tirano - St. Moritz | present |
| Trenino Verde | | Mandas - Arbatax | end of 19th century - present |
| Val Gardena | Trenitalia, ÖBB, DB | Bolzano - Munich | present |
| Venezia | Trenitalia, SŽ, HŽ, MÁV, CFR | Venice - Ljubljana - Zagreb - Budapest - Bucharest | present |