| Rank | Film | Year | Second Weekend
| Opening Weekend
| Change |
| 1 | Star Wars: The Force Awakens | 2015 | $149,202,860 | $247,966,675 | |
| 2 | Avengers: Endgame | 2019 | $147,383,211 | $357,115,007 | |
| 3 | Avengers: Infinity War | 2018 | $114,774,810 | $257,698,183 | |
| 4 | Black Panther | 2018 | $111,658,835 | $202,003,951 | |
| 5 | Jurassic World | 2015 | $106,588,440 | $208,806,270 | |
| 6 | The Avengers | 2012 | $103,052,274 | $207,438,708 | |
| 7 | Inside Out 2 | 2024 | $101,210,550 | $154,201,673 | |
| 8 | Deadpool & Wolverine | 2024 | $96,809,328 | $211,435,291 | |
| 9 | Barbie | 2023 | $93,011,602 | $162,022,044 | |
| 10 | The Super Mario Bros. Movie | 2023 | $92,347,190 | $146,361,865 | |
| 11 | Beauty and the Beast | 2017 | $90,426,717 | $174,750,616 | |
| 12 | Top Gun: Maverick | 2022 | $90,037,011 | $126,707,459 | |
| 13 | Frozen 2 | 2019 | $85,977,773 | $130,263,358 | |
| 14 | Spider-Man: No Way Home | 2021 | $84,548,505 | $260,138,569 | |
| 15 | Incredibles 2 | 2018 | $80,347,651 | $182,687,905 | |
| 16 | A Minecraft Movie | 2025 | $78,503,124 | $162,753,003 | |
| 17 | Avengers: Age of Ultron | 2015 | $77,746,929 | $191,271,109 | |
| 18 | The Lion King | 2019 | $76,621,553 | $191,770,759 | |
| 19 | Avatar | 2009 | $75,617,183 | $77,025,481 | |
| 20 | The Dark Knight | 2008 | $75,166,466 | $158,411,483 | |
| 21 | The Hunger Games: Catching Fire | 2013 | $74,179,601 | $158,074,286 | |
| 22 | Finding Dory | 2016 | $72,959,954 | $135,060,273 | |
| 23 | Captain America: Civil War | 2016 | $72,637,142 | $179,139,142 | |
| 24 | Iron Man 3 | 2013 | $72,525,615 | $174,144,585 | |
| 25 | Star Wars: The Rise of Skywalker | 2019 | $72,389,590 | $177,383,864 | |
| 26 | Shrek 2 | 2004 | $72,170,363 | $108,037,878 | |
| 27 | Star Wars: The Last Jedi | 2017 | $71,565,498 | $220,009,584 | |
| 28 | Spider-Man | 2002 | $71,417,527 | $114,844,116 | |
| 29 | Captain Marvel | 2019 | $69,365,498 | $153,433,423 | |
| 30 | The Batman | 2022 | $66,511,221 | $134,008,624 | |
| 31 | Black Panther: Wakanda Forever | 2022 | $66,482,266 | $181,339,761 | |
| 32 | Guardians of the Galaxy Vol. 2 | 2017 | $65,263,492 | $146,510,104 | |
| 33 | American Sniper | 2014 | $64,628,304 | $89,269,066 | |
| 34 | Rogue One | 2016 | $64,033,768 | $155,081,681 | |
| 35 | Avatar: The Way of Water | 2022 | $63,338,210 | $134,100,226 | |
| 36 | Alice in Wonderland | 2010 | $62,714,076 | $116,101,023 | |
| 37 | Pirates of the Caribbean: Dead Man's Chest | 2006 | $62,345,264 | $135,634,554 | |
| 38 | The Dark Knight Rises | 2012 | $62,101,451 | $160,887,295 | |
| 39 | Guardians of the Galaxy Vol. 3 | 2023 | $62,008,548 | $118,414,021 | |
| 40 | Doctor Strange in the Multiverse of Madness | 2022 | $61,755,804 | $187,420,998 | |
| 41 | The Jungle Book | 2016 | $61,538,821 | $103,261,464 | |
| 42 | Jurassic World: Fallen Kingdom | 2018 | $60,912,195 | $148,024,610 | |
| 43 | It | 2017 | $60,103,110 | $123,403,419 | |
| 44 | Toy Story 4 | 2019 | $59,700,331 | $120,908,065 | |
| 45 | Furious 7 | 2015 | $59,585,930 | $147,187,040 | |
| 46 | Toy Story 3 | 2010 | $59,337,669 | $110,307,189 | |
| 47 | Jurassic World Dominion | 2022 | $59,150,175 | $145,075,625 | |
| 48 | The Hunger Games | 2012 | $58,551,063 | $152,535,747 | |
| 49 | Wonder Woman | 2017 | $58,520,672 | $103,251,471 | |
| 50 | Spider-Man 3 | 2007 | $58,166,256 | $151,116,516 | |