| Actor-politician | Acting career | Party | Office | Year |
| Clay Aiken | Actor and singer | Democratic | Nominee for | 2014 |
| Clay Aiken | Actor and singer | Democratic | Candidate for | 2022 |
| Alan Autry | Actor | Independent | Mayor of Fresno, California | 2001–2009 |
| Rex Bell | Actor | Republican | Lieutenant Governor of Nevada | 1955–1962 |
| Frank Bogert | Actor, rodeo announcer | Republican | Mayor of Palm Springs, California | 1958–1966, 1982–1988 |
| Sonny Bono | Actor and singer-songwriter | Republican | Mayor of Palm Springs, California | 1988–1992 |
| Sonny Bono | Actor and singer-songwriter | Republican | U.S. Representative - | 1995–1998 |
| Kimberlin Brown | Actress | Republican | Candidate for | 2018 |
| Marilyn Chambers | Pornographic film actress | Personal Choice Party
| Nominee for Vice President | 2004 |
| Marilyn Chambers | Pornographic film actress | Boston Tea Party | Alternate write-in candidate to vice-presidential running mate | 2008 |
| Wendell Corey | Actor | Republican | Member of the Santa Monica City Council | 1965–1968 |
| Wendell Corey | Actor | Republican | Candidate for U.S. Representative | 1966 |
| Albert Dekker | Actor | Democratic | Member of the California State Assembly | 1945–1947 |
| Cherie DeVille | Pornographic film actress | Democratic | Candidate for President | 2020 |
| Bob Dornan | Actor | Republican | U.S. Representative - California 27, 38, 46 | 1977–1983, 1985–1997 |
| Bob Dornan | Actor | Republican | Candidate for U.S. Senate | 1982 |
| Bob Dornan | Actor | Republican | Candidate for President | 1996 |
| Helen Gahagan Douglas | Actress in Broadway theatre and film | Democratic | U.S. Representative- | 1945–1951 |
| Helen Gahagan Douglas | Actress in Broadway theatre and film | Democratic | Nominee for U.S. Senate | 1950 |
| Clint Eastwood | Actor | Republican | Mayor of Carmel-by-the-Sea, California | 1986–1988 |
| Charles Farrell | Actor | | Mayor of Palm Springs, California | 1947–1955 |
| Joe Flynn | Actor | Republican | Candidate for the Ohio Senate | 1950 |
| Al Franken | Actor and comedian, radio personality | Democratic | U.S. Senator - Minnesota | 2009–2018 |
| John Gavin | Actor | Republican | U.S. Ambassador to Mexico | 1981–1986 |
| Melissa Gilbert | Actress | Democratic | Candidate for | 2016 |
| Vic Gilliam | Part-time actor | Republican | Member of the Oregon House of Representatives | 2007–2017 |
| Fred Grandy | Actor, radio personality | Republican | U.S. Representative - Iowa 6 and 5 | 1987–1995 |
| Fred Grandy | Actor, radio personality | Republican | Candidate for Governor | 1996 |
| Hill Harper | Actor '' | Democratic | Candidate for U.S. Senate in Michigan | 2024 |
| J. G. Hertzler | Actor | Democratic Independent | Ulysses, New York town councillor | 2013–2020 |
| J. G. Hertzler | Actor | Democratic Independent | Candidate for | 2018 |
| Gil Hill | Actor | Democratic | Member of the Detroit City Council | 1990–2001 |
| Gil Hill | Actor | Democratic | Candidate for Mayor of Detroit | 2001 |
| Glenn Jacobs | Actor and professional wrestler | Republican | Mayor of Knox County, Tennessee | 2018–present |
| Ben Jones | Actor | Democratic | U.S. Representative - | 1989–1993 |
| Jack Kelly | Actor | Republican | Mayor of Huntington Beach, California | 1983–1986 |
| Sheila Kuehl | Former child actress | Democratic | California State Assembly | 1994–2000 |
| Sheila Kuehl | Former child actress | Democratic | California State Senate | 2000–2008 |
| Sheila Kuehl | Former child actress | Democratic | Los Angeles County Board of Supervisors | 2014–2022 |
| Nancy Kulp | Actor | Democratic | Candidate for | 1984 |
| Sonny Landham | Actor | Republican | Candidate for Governor of Kentucky | 2003 |
| Sonny Landham | Actor | Libertarian | Candidate for U.S. Senate in Kentucky | 2008 |
| Al Lewis | Actor | Green | Candidate for Governor of New York | 1998 |
| John Davis Lodge | Actor | Republican | U.S. Representative - | 1947–1951 |
| John Davis Lodge | Actor | Republican | Governor of Connecticut | 1951–1955 |
| Bob Mathias | Actor | Republican | U.S. Representative - | 1967–1975 |
| Christopher Mitchum | Actor | Republican | Candidate for California State Assembly | 1998 |
| Christopher Mitchum | Actor | Republican | Candidate for | 2012, 2014 |
| George Murphy | Actor | Republican | U.S. Senator - California | 1965–1971 |
| Diane Neal | Actor | Independent | Candidate for | 2018 |
| Cynthia Nixon | Actress | Democratic | Candidate for Governor of New York | 2018 |
| Park Overall | Actress | Democratic | Candidate for U.S. Senate in Tennessee | 2008 |
| Stephen Peace | Actor and producer | Democratic | California State Assembly | 1982–1992 |
| Stephen Peace | Actor and producer | Democratic | California Senate | 1993–2002 |
| Richard Petty | Actor, professional racecar driver | Republican | Member of the Randolph County, North Carolina Commission | 1978–1994 |
| Richard Petty | Actor, professional racecar driver | Republican | Candidate for Secretary of State of North Carolina | 1996 |
| Steven Michael Quezada | Actor | Democratic | Member of the Albuquerque, New Mexico school board | 2013–2017 |
| Steven Michael Quezada | Actor | Democratic | Member of the Bernalillo County, New Mexico Commission | 2017–2025 |
| Trey Radel | Actor | Republican | U.S. Representative - | 2013–2014 |
| Ronald Reagan | Actor | Republican | Governor of California | 1967–1975 |
| Ronald Reagan | Actor | Republican | President of the United States | 1981–1989 |
| Tex Ritter | Actor and country music singer | Republican | Candidate for U.S. Senate in Tennessee | 1970 |
| Will Rogers | Actor | Democratic | Mayor of Beverly Hills, California | 1928 |
| Will Rogers Jr. | Actor | Democratic | U.S. Representative - | 1943–1944 |
| Antonio Sabàto Jr. | Model and actor | Republican | Candidate for | 2018 |
| Ben Savage | Actor | Democratic | Candidate for | 2024 |
| Arnold Schwarzenegger | Actor and retired bodybuilder | Republican | Governor of California | 2003–2011 |
| Jerry Springer | Actor and talk show host | Democratic | Candidate for | 1970 |
| Jerry Springer | Actor and talk show host | Democratic | Member of Cincinnati City Council | 1971–1974 |
| Jerry Springer | Actor and talk show host | Democratic | Mayor of Cincinnati | 1977–1978 |
| George Takei | Actor | Democratic | Alternate delegate to Democratic National Convention | 1972 |
| George Takei | Actor | Democratic | Candidate for Los Angeles City Council | 1973 |
| George Takei | Actor | Democratic | Candidate for California State Assembly | 1980 |
| Shirley Temple Black | Former child actor | Republican | Candidate for | 1967 |
| Shirley Temple Black | Former child actor | Republican | U.S. Ambassador to Ghana | 1974–1976 |
| Shirley Temple Black | Former child actor | Republican | U.S. Chief of Protocol | 1976–1977 |
| Shirley Temple Black | Former child actor | Republican | U.S. Ambassador to Czechoslovakia | 1989–1992 |
| Fred Thompson | Actor | Republican | U.S. Senator - Tennessee | 1994–2003 |
| Fred Thompson | Actor | Republican | Candidate for President | 2008 |
| Jesse Ventura | Actor and professional wrestler | Independent Reform Independence | Mayor of Brooklyn Park, Minnesota | 1991–1995 |
| Jesse Ventura | Actor and professional wrestler | Independent Reform Independence | Governor of Minnesota | 1999–2003 |
| Ralph Waite | Actor | Democratic | Candidate for | 1990 |
| Ralph Waite | Actor | Democratic | Candidate for | 1998 |
| Ralph Waite | Actor | Democratic | Candidate for | 1998 |
| Noble Willingham | Actor | Republican | Candidate for | 2000 |