| Protocol | Used by | Defunct clients |
| ActivityPub | Friendica, Libervia, Lemmy, Mastodon, Micro.blog, Nextcloud, PeerTube, Pixelfed, Pleroma | |
| Advanced Peer-to-Peer Networking (APPN) | Systems Network Architecture | |
| BitTorrent | BitComet, Bitlord, BitTorrent, Flashget, FrostWire, Getright, i2psnark, libtorrent, μTorrent, Miro, MLDonkey, Popcorn Time, qBittorrent, Shareaza, Tixati, Transmission, Tribler, Xunlei, Vuze, etc. | Trustyfiles, Vagaa |
| Direct Connect | ApexDC++, BCDC++, DC++, MLDonkey, Shareaza | NeoModus Direct Connect |
| eDonkey | aMule, Bitcomet, eMule, Flashget, imule, MLDonkey, Neoloader, Shareaza, Xunlei | FileScope, edonkey2000, Vagaa |
| FastTrack | MLDonkey, XNap | Grokster, Kazaa, Kazaa Lite, Trustyfiles |
| Freenet | Freenet, Frost | |
| Gnutella | Cabos, Envy, Gnucleus, gtk-gnutella, iphex, Phex, Shareaza, WireShare | Acquisition, BearShare, FileScope, iMesh, LimeWire, Morpheus, Trustyfiles |
| Gnutella2 | Envy, gtk-gnutella, MLDonkey, Shareaza | FileScope |
| Libp2p | IPFS, Orbit, Ethereum | |
| OpenFT | giFT, MLDonkey | |
| OpenNap | Audiognome, Lopster, SunshineUN, TekNap, Utatane, XNap, Winlop, WinMX | FileScope, Morpheus, Napigator |
| Overnet | XNap | edonkey2000, Overnet |
| RetroShare | RetroShare, elRepo.io, Xeres | UnseenP2P |
| Soulseek | Nicotine+, Seeker, slskd, Soulseek NS, SoulseekQt | GoSeek, iSoul, MewSeek, Museek, Museek+, Nicotine, PySoulSeek, SolarSeek, Soulseex |
| Tox | qTox, μTox, Toxic, Toxygen, TRIfA, Antox, Isotoxin, jTox, Protox, aTox | |
| WebTorrent | WebTorrent Desktop, Brave (web browser) | |
| WinMX Peer Networking Protocol | OurMX, WinMX, WinPY | |
| WebRTC | PeerTube | |