| Name | Chapter | Notability | References |
| Pi | First woman Vice President at IBM | |
| Delta Rho | President of TNA Entertainment | |
| Mary Maxwell Gates | Beta Pi | Banker, civic activist, non-profit executive, and mother of Bill Gates | |
| Whitney Wolfe Herd | Gamma Phi | Founder and CEO of Bumble, and a co-founder of Tinder | |
| Beta Beta | Founder, creative director, and namesake of the designer brand Elizabeth McKay | |
| Upsilon | Chairwoman, President, and CEO of IBM Corporation | |
| Omega | Co-founder, designer, and namesake of the designer brand Kate Spade New York | |
| Beta Theta | Philanthropist and wife of Sam Walton, founder of Wal-Mart | |
| Name | Chapter | Notability | References |
| Gamma Xi | Miss America 1943 | |
| Delta Tau | Daytime Emmy Award-winning actress on General Hospital | |
| Gamma Xi | Reality show contestant in The Hills and Laguna Beach: The Real Orange County | |
| Delta Tau | Actress, played Brooke Davis on One Tree Hill | |
| Beta Eta (Deuteron) | Miss America 1989, former Fox News anchor, former The Early Show anchor | |
| Epsilon Pi | Actress and reality show contestant known for her participation in The Real World: San Diego and the films Sucker Punch and Sorority Row | |
| Iota | Stage actress and writer, known for her work on I'm Getting My Act Together and Taking It on the Road | |
| Beta Tau | Miss Rhode Island 2015 | |
| Iota | Emmy Award-winning screenwriter for The Lily Tomlin Special | |
| Delta Xi | Actress, Get Smart | |
| Theta | Singer, subject of the film With a Song in My Heart | |
| Delta Beta | Actress, played Monica Reyes on The X-Files | |
| Delta Tau | Actress, Awkward. | |
| Epsilon Delta | Actress, played Babe Carey on All My Children | |
| Gamma Phi | Actress, plays Emily Stewart on As the World Turns | |
| Delta | Grammy Award-winning conductor with the Chicago Symphony Orchestra, founder of the Chicago Symphony Chorus | |
| Delta Rho | Actress, known for her work in Scarecrow and Mrs. King as well as playing Sabrina Duncan on Charlie's Angels | |
| Beta Chi | Actress, known for her roles in A Time to Kill, Kiss the Girls, Double Jeopardy | |
| Beta Theta | Singer, vocal group Pentatonix | |
| Upsilon | Actress, played Rachel Zane on Suits, and Duchess of Sussex | |
| Gamma Omega | Actress, Grand Theft Auto | |
| Gamma Phi | Actress, known for her work on Felicity and Brothers and Sisters | |
| Eta | Stage and screen actress, known for her work on Sunset Boulevard | |
| Jane Pauley | Delta | Television journalist and anchor on Today and Dateline NBC | |
| Delta Kappa | Actress, MASH | |
| Zeta Theta | Singer-songwriter | |
| Delta | Television writer, known for her work on The Steve Allen Show and I Love Lucy | |
| Eta Beta | Model and reality show contestant in Laguna Beach: The Real Orange County | |
| Epsilon Mu | Country music singer | |
| Eta | Emmy Award and Golden Globe Award-winning actress | |
| Beta Tau | Correspondent and co-host of LX New York | |
| Gamma Nu | Miss Arkansas 2016 and Miss America 2017 | |
| Gamma Beta | Emmy Award-winning stage and screen actress, known for her work in Cat on a Hot Tin Roof | |
| Alpha (Deuteron) | Actress, played Nancy Hughes on As the World Turns | |
| Name | Chapter | Notability | References |
| Gamma Pi | Professional tennis player, runner-up at the 1965 Cincinnati Masters | |
| Beta Kappa | Cyclist, two-time [Summer Summer Olympic Games|Olympic Games|Olympic] gold medalist in the individual time trial in 2008 and [Cycling at the Cycling at the 2012 Summer Olympics – Women's road time trial|2012 Summer Olympics – Women's road time trial|2012]. | |
| Delta Epsilon | Professional golfer, won the 1949 Titleholders Championship | |
| Chi | Professional golfer and a founding member of Ladies Professional Golf Association, inductee of the World Golf Hall of Fame | |
| Delta Epsilon | Professional golfer, member of the LPGA | |
| Alana Cook | Beta Eta Deuteron | Professional soccer player | |
| Delta Kappa | Professional tennis player, won the U.S. Women's Open in 1954 and 1955, inductee of the International Tennis Hall of Fame | |
| Eleanor (Elle) Logan | Beta Eta Deuteron | Rower, the first American rower to win a gold medal in three consecutive Olympics | |
| Beta Eta Deuteron | Professional soccer player, Sky Blue FC. Olympic gold medalist with the U.S. Women's National Team at the London Games 2012. 2015 and 2019 FIFA Women's World Cup Champion. | |
| Pi (Deuteron) | Professional tennis player, won the French Championships four times, the U.S. Championships seven times, and Wimbledon eight times | |
| Upsilon | Received the gold for the 100 m at the 1928 Olympics, and again at the 1936 Olympics for the 4 × 100 m relay | |
| Melissa Seidemann | Beta Eta Deuteron | Water polo player, 2012 Olympic Gold medal | |
| Hollis Stacy | Delta Epsilon | Professional golfer, won the U.S. Women's Open in 1977, 1978, and 1984 | |
| Maggie Steffens | Beta Eta Deuteron | Water polo player, 2012 Olympic Gold medal | |
| Evelyn Stevens | Epsilon Chi | Racing cyclist | |
| Genevra Stone | Zeta Phi | Rower, Single Sculls, competed in London 2012, and earned Silver medal in Rio 2016 | |
| Gamma Phi | Professional ice dancer, represented Lithuania at Sochi 2014, won bronze at 2011 Skate America, and placed in the top ten at two European Championships | |
| Gamma Xi | Swimmer, received two golds at the 1964 Olympics, and again at the 1963 Pan American Games | |
| Beta Nu | Gymnast, judge at the 1984 Summer Olympics | |
| Gamma Delta | Canadian swimmer, won the Lou Marsh Trophy | |
| Pi (Deuteron) | Professional tennis player, won the U.S. Championships in 1909, 1910, 1911, and 1919 | |