| Title | Director | Cast | Genre | Notes |
| 2010 | - | - | - | - |
| 18 Years Later | Edoardo Leo | Edoardo Leo, Marco Bonini, Sabrina Impacciatore | Comedy-drama | |
| 20 Cigarettes | Aureliano Amadei | Vinicio Marchioni, Carolina Crescentini | Drama | |
| Angel of Evil | Michele Placido | Kim Rossi Stuart, Michele Placido, Filippo Timi, Paz Vega | Crime | |
| Basilicata Coast to Coast | Rocco Papaleo | Rocco Papaleo, Alessandro Gassman, Giovanna Mezzogiorno | Comedy | |
| Benvenuti al Sud | Luca Miniero | Claudio Bisio, Alessandro Siani, Angela Finocchiaro, Valentina Lodovini | Comedy | |
| Certified Copy | Abbas Kiarostami | Juliette Binoche, William Shimell | Drama | French-Italian-Belgian co-production |
| Come Undone | Silvio Soldini | Alba Rohrwacher, Pierfrancesco Favino, | Drama | Berlin Film Festival |
| Dark Love | Antonio Capuano | Luisa Ranieri, Valeria Golino, Fabrizio Gifuni | Drama | |
| Die | Dominic James | Elias Koteas, Emily Hampshire, Caterina Murino | Thriller | Canadian-Italian co-production |
| Draquila – L'Italia che trema | Sabina Guzzanti | Sabina Guzzanti | Documentary | Entered the 2010 Cannes Film Festival |
| The End Is My Beginning | Jo Baier | Bruno Ganz, Elio Germano | Drama | |
| Exit: una storia personale | Massimiliano Amato | Luca Guastini | Drama | |
| The Father and the Foreigner | Ricky Tognazzi | Alessandro Gassman, Amr Waked | Drama | |
| The First Assignment | Giorgia Cecere | Isabella Ragonese | Drama | |
| The First Beautiful Thing | Paolo Virzì | Valerio Mastandrea, Micaela Ramazzotti, Stefania Sandrelli, Claudia Pandolfi | Drama | Italian entry for the Best Foreign Language Film at the 83rd Academy Awards |
| From the Waist Up | Gianfrancesco Lazotti | Cristiana Capotondi, Filippo Nigro, Nicoletta Romanoff | Drama | |
| Gorbaciof | Stefano Incerti | Toni Servillo, Yang Mi | Drama | |
| Happy Family | Gabriele Salvatores | Margherita Buy, Diego Abatantuono, Fabrizio Bentivoglio | Comedy | |
| Hayfever | Laura Luchetti | Andrea Bosca, Diane Fleri, Giulia Michelini | Romance | |
| I Am Love | Luca Guadagnino | Tilda Swinton, Marisa Berenson | Drama | Music By John Adams |
| Into Paradiso | Paola Randi | Gianfelice Imparato, Peppe Servillo | Comedy | Entered into the 67th Venice International Film Festival |
| Kiss Me Again | Gabriele Muccino | Stefano Accorsi, Pierfrancesco Favino | Romance | Sequel of The Last Kiss |
| Loose Cannons | Ferzan Özpetek | Riccardo Scamarcio, Alessandro Preziosi, Carolina Crescentini, Nicole Grimaudo | Comedy | Entered the 60th Berlin International Film Festival |
| Lost Kisses | Roberta Torre | Donatella Finocchiaro, Carla Marchese, Piera Degli Esposti | Comedy-drama | Entered into the 68th Venice International Film Festival |
| Love & Slaps | Sergio Castellitto | Sergio Castellitto, Laura Morante, Enzo Jannacci, Marco Giallini | Comedy | |
| Marriage and Other Disasters | Nina Di Majo | Margherita Buy, Fabio Volo, Francesca Inaudi | Comedy | |
| Martino's Summer | Massimo Natale | Treat Williams, Luigi Ciardo | Drama | |
| Men vs. Women | Fausto Brizzi | Paola Cortellesi, Fabio De Luigi, Sarah Felberbaum, Claudio Bisio | Comedy | |
| Me, Them and Lara | Carlo Verdone | Carlo Verdone, Laura Chiatti, Anna Bonaiuto, Marco Giallini | Comedy | |
| The Mouth of the Wolf | Pietro Marcello | Mary Monaco | Documentary | Teddy Award winner |
| News from the Excavations | Emidio Greco | Giuseppe Battiston, Ambra Angiolini, Iaia Forte | Drama | |
| La nostra vita | Daniele Luchetti | Elio Germano, Isabella Ragonese, Raoul Bova | Drama | In competition at the 2010 Cannes Film Festival |
| Parents and Children: Shake Well Before Using | Giovanni Veronesi | Silvio Orlando, Luciana Littizzetto, Michele Placido, Margherita Buy | Comedy | |
| Passione | John Turturro | John Turturro, Fiorello, Massimo Ranieri, Lina Sastri | Documentary | Entered into the 67th Venice International Film Festival |
| La passione | Carlo Mazzacurati | Silvio Orlando, Cristiana Capotondi, Stefania Sandrelli, Kasia Smutniak | Comedy-drama | Entered into the 67th Venice International Film Festival |
| La pecora nera | Ascanio Celestini | Maya Sansa, Giorgio Tirabassi, Ascanio Celestini | Comedy | Entered into the 67th Venice International Film Festival |
| Le Quattro Volte | Michelangelo Frammartino | Giuseppe Fuda | Drama | |
| A Quiet Life | Claudio Cupellini | Toni Servillo, Juliane Köhler | Neo-noir | |
| The Santa Claus Gang | Paolo Genovese | Aldo, Giovanni & Giacomo, Angela Finocchiaro | Comedy | |
| School Is Over | Valerio Jalongo | Valeria Golino, Vincenzo Amato, Antonella Ponziani | Drama | |
| A Second Childhood | Pupi Avati | Fabrizio Bentivoglio, Francesca Neri, Lino Capolicchio, Serena Grandi | Drama | |
| The Solitude of Prime Numbers | Saverio Costanzo | Alba Rohrwacher, Luca Marinelli, Isabella Rossellini | Drama | Entered into the 67th Venice International Film Festival |
| Sorry If I Want to Marry You | Federico Moccia | Raoul Bova, Michela Quattrociocche, Cecilia Dazzi | Romantic comedy | |
| Sul mare | Alessandro D'Alatri | Martina Codecasa, Vincenzo Merolla | Romance | |
| Ti presento un amico | Carlo Vanzina | Raoul Bova, Martina Stella, Barbora Bobuľová | Romantic comedy | |
| The Trick in the Sheet | Alfonso Arau | Maria Grazia Cucinotta, Geraldine Chaplin, Anne Parillaud | Comedy | |
| Ubaldo Terzani Horror Show | Gabriele Albanesi | Paolo Sassanelli, Giuseppe Soleri | Horror | |
| Unlikely Revolutionaries | Lucio Pellegrini | Pierfrancesco Favino, Giuseppe Battiston, Fabio Volo, Claudia Pandolfi | Comedy | |
| The Youngest Son | Pupi Avati | Christian De Sica, Luca Zingaretti, Laura Morante | Comedy-drama | |
| We Believed | Mario Martone | Luigi Lo Cascio, Valerio Binasco, Toni Servillo, Luca Zingaretti | Drama | Entered into the 67th Venice International Film Festival |
| The Woman of My Dreams | Luca Lucini | Alessandro Gassman, Luca Argentero, Valentina Lodovini | Comedy | |