| # | Image | Name
Birth date | Country | Comment | Missions |
| 1 | 80px | Arnaldo Tamayo Méndez
January 29, 1942 | | First person from Latin America to fly in space. First person of African descent in space. First Cuban in space. | Soyuz 38 |
| 2 | 80px | Rodolfo Neri Vela
February 19, 1952 | | First Mexican in space. | STS-61-B |
| 3 | 80px | Franklin Chang-Diaz
April 5, 1950 |
| First Costa Rican astronaut | STS-61-C
STS-34
STS-46
STS-60
STS-75
STS-91
STS-111 |
| 4 | 80px | Sidney M. Gutierrez
June 27, 1951 |
| First U.S.-born Hispanic astronaut | STS-40
STS-59 |
| 5 | 80px | Ellen Ochoa
May 10, 1958 |
| First female Hispanic astronaut | STS-56
STS-66
STS-96
STS-110 |
| 6 | 80px | Michael Lopez-Alegria
May 30, 1958 | -
| First Spanish-born astronaut | STS-73
STS-92
STS-113
Soyuz TMA-9
Axiom Mission 1 |
| 7 | 80px | Carlos I. Noriega
October 8, 1959 |
| First Peruvian-born astronaut | STS-84
STS-97 |
| 8 | 80px | Pedro Duque
March 14, 1963 | | First Spanish astronaut without dual citizenship | STS-95
Soyuz TMA-3/2 |
| 9 | 80px | John D. Olivas
May 25, 1965 |
| First Mexican-American Spacewalker | STS-117
STS-128 |
| 10 | 80px | George D. Zamka
June 29, 1962 |
| | STS-120
STS-130 |
| 11 | 80px | Joseph M. Acaba
May 17, 1967 |
| First Puerto Rican astronaut | STS-119
Soyuz TMA-04M
Soyuz MS-06 |
| 12 | 80px | José M. Hernández
August 7, 1962 |
| First migrant farm worker in space. | STS-128 |
| 13 | 80px | Serena M. Auñón
April 9, 1976 |
| | Soyuz MS-09 |
| 14 | | Francisco Rubio
December 11, 1975 |
( El Salvador
|
