List of American films of 2006
This is a list of American films released in 2006.
Box office
The highest-grossing American films released in 2006, by domestic box office gross revenue, are as follows:| Rank | Title | Distributor | Domestic gross |
| 1 | Pirates of the Caribbean: Dead Man's Chest | Disney | $423,315,812 |
| 2 | Night at the Museum | 20th Century Fox | $250,863,268 |
| 3 | Cars | Disney | $244,082,982 |
| 4 | X-Men: The Last Stand | 20th Century Fox | $234,362,462 |
| 5 | The Da Vinci Code | Sony | $217,536,138 |
| 6 | Superman Returns | Warner Bros. | $200,081,192 |
| 7 | Happy Feet | Warner Bros. | $198,000,317 |
| 8 | Ice Age: The Meltdown | 20th Century Fox | $195,330,621 |
| 9 | Casino Royale | Sony | $167,445,960 |
| 10 | The Pursuit of Happyness | Sony | $163,566,459 |