| # | Date | Film | Gross | Notes |
| 1 | | Twilight | $287,433 | |
| 2 | | Twilight | $153,007 | |
| 3 | | Yes Man | $167,997 | |
| 4 | | The Curious Case of Benjamin Button | $155,449 | |
| 5 | | The Curious Case of Benjamin Button | $136,475 | |
| 6 | | The Curious Case of Benjamin Button | $105,565 | |
| 7 | | Valkyrie | $200,414 | |
| 8 | | Bedtime Stories | $182,093 | |
| 9 | | Bedtime Stories | $187,984 | |
| 10 | | Bedtime Stories | $104,267 | |
| 11 | | Bedtime Stories | $82,986 | |
| 12 | | Underworld: Rise of the Lycans | $75,006 | |
| 13 | | Bedtime Stories | $53,213 | |
| 14 | | Monsters vs. Aliens | $287,516 | |
| 15 | | Monsters vs. Aliens | $201,337 | |
| 16 | | Race to Witch Mountain | $124,997 | |
| 17 | | Race to Witch Mountain | $101,432 | |
| 18 | | X-Men Origins: Wolverine | $388,721 | |
| 19 | | X-Men Origins: Wolverine | $162,230 | |
| 20 | | Angels & Demons | $601,689 | |
| 21 | | Angels & Demons | $500,108 | |
| 22 | | Night at the Museum: Battle of the Smithsonian | $282,581 | |
| 23 | | Terminator Salvation: The Future Begins | $355,924 | |
| 24 | | Up | $688,885 | |
| 25 | | Up | $554,330 | |
| 26 | | Transformers: Revenge of the Fallen | $566,091 | |
| 27 | | Ice Age: Dawn of the Dinosaurs | $1,381,331 | Ice Age: Dawn of the Dinosaurs is the highest weekend opening since The Simpsons Movie, and It's the most viewed film in the country since Titanic with a total gross of $7 mil. |
| 28 | | Ice Age: Dawn of the Dinosaurs | $1,139,680 | |
| 29 | | Harry Potter and the Half Blood Prince | $1,218,763 | |
| 30 | | Up | $1,710,885 | Up with $1.7 mil gross broke Ice Age: Dawn of the Dinosaurss record and it is the highest gross for a week and $5 mil gross to date. |
| 31 | | Ice Age: Dawn of the Dinosaurs | $286,526 | |
| 32 | | G-Force | $240,471 | |
| 33 | | G-Force | $144,199 | |
| 34 | | G-Force | $97,054 | |
| 35 | | Orphan | $103,593 | |
| 36 | | Orphan | $92,758 | |
| 37 | | The Taking of Pelham 123 | $83,565 | |
| 38 | | The Taking of Pelham 123 | $61,957 | |
| 39 | | Cloudy with a Chance of Meatballs | $164,873 | |
| 40 | | The Final Destination | $165,958 | |
| 41 | | The Final Destination | $119,688 | |
| 42 | | Inglourious Basterds | $123,111 | |
| 43 | | Inglourious Basterds | $100,612 | |
| 44 | | Michael Jackson's This Is It | $238,978 | |
| 45 | | A Christmas Carol | $187,756 | |
| 46 | | 2012 | $973,326 | |
| 47 | | 2012 | $778,394 | |
| 48 | | The Twilight Saga: New Moon | $773,310 | |
| 49 | | The Twilight Saga: New Moon | $365,545 | |
| 50 | | The Twilight Saga: New Moon | $122,221 | |
| 51 | | Avatar † | $1,085,054 | |
| 52 | | Avatar † | $975,811 | |