| Alumni | Class | Reason for notability |
| 1931 | Musician |
| 1943 | two-time Pulitzer Prize, commentator on the Masterpiece Theatre on |
| 1958 | Jazz musician, Grammy Award winner |
| 1928 | Abstract expressionist painter |
| 1962 | Author of over 50 science fiction/fantasy novels |
| 1964 | Broadway actor, Tony Award nominee |
| 1954* | Avant garde composer |
| 1933 | Painter; works are in permanent collections at the Baltimore Museum of Art, The Phillips Collection, and the Metropolitan Museum of Art in New York City |
| 1918 | Musician, conductor |
| 1904 | Character actor and voice narrator in film, television, and stage |
| 1933 | Author, screenwriter; helped create the film/television cartoon character of "Mr. Magoo" |
| 1967? | Rock musician, radio host |
| 1940 | Radio talk show host in Washington, D.C. and New York |
| 1984 | Author |
| 1933 | Game show host in New York City during the 1950s and 1960s. |
| 1946 | News anchor WBAL-TV, local TV variety and game show host plus announcer |
| 1928 | Writer, won Academy Award ("Oscar") and Golden Globe for screenplay of Battleground War film |
| 1937 | Television and radio host |
| 1993 | Singer, member of Dru Hill |
| 1932 | Poet; literary critic; professor, Johns Hopkins University; Pulitzer Prize winner |
| 1919 | Poet and founder of Aesthetic Realism |
| 1962 | Actor, appeared in 1990s legal television drama L.A. Law and earlier Diner |
| 1942 | Writer, author of Exodus |
| 1930 | Television and film writer, producer; director; credits include Gunsmoke, Rawhide, The Virginian and Playhouse 90. |
| 1929 | Composer |
| 1870 | Author, civil libertarian, and attorney |
| Alumni | Class | Reason for notability |
| 1897 | Economist, Yale University; President, American Economic Association |
| 1961 | Bishop, Fifth Episcopal District, African Methodist Episcopal Church |
| 1868 | Political scientist, Johns Hopkins University, University of Pennsylvania, Princeton University; President, American Political Science Association |
| 1928 | Chemist; president, Rice University and the University of Texas at Austin; National Medal of Science; Vannevar Bush Award |
| 1928 | Former President, American Jewish Congress |
| 1953 | Biographer of Benjamin Franklin, du Pont Winterthur Professor of English at the University of Delaware |
| 1967 | President, University of Baltimore, former Dean, Howard University School of Law; 47th Mayor, City of Baltimore |
| | Methodist minister, educator, and the co-founder of Goucher College |
| 1894 | Longest serving superintendent, Baltimore City Public School System 1924–1945 |
| 1888 | President, Towson University; Superintendent, Baltimore City Public School System |
| Alumni | Class | Reason for notability |
| 1967 | Delegate, District 43, Baltimore ; longest serving chairman of the Baltimore City Delegation |
| 1905 | Delegate, Baltimore County, 1914 |
| 1926 | Delegate ; Judge, Baltimore Supreme Bench |
| | Delegate, Baltimore County and State Senator, Baltimore County |
| 1994 | Delegate, District 43A Baltimore |
| 1968 | Delegate, District 40, Baltimore City |
| 1964 | Delegate, District 7 Baltimore County |
| 1964 | Delegate, District 34, Harford County |
| 1968 | Delegate, District 41, Baltimore City |
| 1966 | State Senator, District 40, Baltimore City ; Delegate |
| 1949 | State Senator, District 44, Baltimore City |
| 1964 | State Senator, District 45, Baltimore City |
| 1950 | Lieutenant Governor ; President of Maryland State Senate ; State Senator |
| 1953 | State Senator, District 45, Baltimore County |
| Alumni | Class | Reason for notability |
| 1858 | Supreme Bench of Baltimore City, Judge |
| 1915 | United States District Court for the Eastern District of New York, Judge |
| 1946 | Circuit Court, Baltimore City, Chief Judge, Judge |
| 1919 | Maryland Court of Appeals, Chief Judge, Judge |
| 1899 | Maryland Court of Appeals, Chief Judge, Judge |
| 1937 | United States Court of Appeals for the Fourth Circuit, Circuit Judge |
| 1917 | Maryland Court of Appeals, Judge |
| 1939 | Circuit Court, Baltimore City, Judge |
| 1965 | United States District Court for the District of Maryland, Judge |
| 1877 | United States Court of Appeals for the Fourth Circuit, Circuit Judge United States District Court for the District of Maryland, Judge ; U.S. Attorney for the District of Maryland |
| 1936 | Supreme Court of Puerto Rico, Chief Justice, Associate Justice |
| 1909 | United States Court of Appeals for the Fourth Circuit, Chief Judge, Circuit Judge ; United States Solicitor General |
| 1890 | United States Court of Appeals for the Fourth Circuit, Circuit Judge |
| 1925 | Supreme Bench of Baltimore City, Judge |
| 1918 | United States District Court for the District of Maryland, Judge |
| 1954 | Maryland Court of Appeals, Judge ; Maryland Court of Special Appeals, Chief Judge, Judge |
| Alumni | Class | Reason for notability |
| 1989 | Youngest person to become a doctor |
| 1951 | Mathematician; Askey-Wilson polynomials |
| 1949 | Polymer and plastics researcher |
| 1932 | Surgeon, first to do heart transplant; physician to Hubert Humphrey |
| 1954 | Neurologist |
| 1913 | National Advisory Committee for Aeronautics, NASA |
| 1938 | Chemical engineer, metallurgist |
| 1949 | Mathematician, engineer, inventor of polyominoes |
| 1928 | Chemist, former president, University of Texas, Rice University |
| 1878 | Physiologist; pioneer of the use of heparin as a blood anticoagulant; dean, Johns Hopkins University School of Medicine |
| 1960 | Mathematician; Grothendieck-Katz p-curvature conjecture |
| 1957 | Ecologist, Princeton University |
| 1866 | Botanist |
| 1939 | Physicist; professor, Rensselaer Polytechnic Institute; Oersted Medal |
| 1943 | Biochemist, molecular endocrinologist; Nobel Prize in Physiology or Medicine 1994 |
| 1922 | Biologist, geneticist |
| 1967 | Pediatrician; medical expert on adolescents |
| 1927 | Theoretical physicist; Wolf Prize in Physics |
| 1909 | Sanitary engineer; inventor of modern water treatment techniques |
| Alumni | Class | Reason for notability |
| 1965 | College soccer, head coach, College of William & Mary |
| 1921* | Baseball, 2nd baseman, Philadelphia Athletics and Boston Red Sox, |
| 1937 | Baseball, pitcher, New York Yankees |
| 1940 | Basketball, head coach, Fort Wayne/Detroit Pistons |
| 1968 | Football, wide receiver, New York Giants |
| 2017 | Football, Linebacker, Baltimore Ravens |
| 1999 | Football, wide receiver, Arizona Cardinals, Detroit Lions |
| 1926 | Lacrosse, member, National Lacrosse Hall of Fame |
| 1921 | Baseball, Manager, New York Yankees and Cincinnati Reds |
| 1899 | Lacrosse, coach, Johns Hopkins University, namesake Schmeisser Award; US Olympian |
| 2012 | Offensive tackle Dallas Cowboys, New York Jets |
| 1918 | Baseball, pitcher, Chicago White Sox |