Lelio Orci


Lelio Orci was an Italian scientist in the field of endocrinology and diabetes and emeritus professor in the Department of Morphology at the University of Geneva Medical School.
Orci was born in 1937 in San Giovanni Incarico. He received his BA in 1958. He studied medicine at the University of Rome, graduating in 1964. In 1966, he moved to the University of Geneva where he worked ever since. He was chair of the Department of Morphology from 1976 until his retirement in 2000, transitioning to professor emeritus.
Orci is known for his work on cell and tissue biology using electron microscopy. In the first part of his research career, Orci's laboratory largely studied the organization of the pancreatic islet of Langerhans, as well as the secretion pathway of insulin from the beta cell. His group was the first to utilize immunogold labelling to localize intracellular proteins, and among the first to use freeze-fracture with electron microscopy to study a cell's internal organization. In 1984, he began collaborating with James Rothman on the work in vesicle trafficking that eventually earned Rothman, Randy Schekman, and Thomas C. Südhof the Nobel Prize.

Awards

The Lelio Orci Award for advances in cell biology was established in 2015.

Personal life

In a 2020 obituary, Orci was described as having a "strong, flamboyant personality" and "infectious enthusiasm" for science. He traveled rarely, instead working long hours in his laboratory.
Orci had a wife, Catherine, and three children.