TFCP2
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.
TFCP2 is also called Late SV40 factor and it is induced by well-known oncogene AEG-1. LSF also acts as an oncogene in hepatocellular carcinoma. LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9.
Along with its main oncogene function in hepatocellular carcinoma, it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition, allergic response, inflammation and Alzheimer's disease. The small molecule FQI1 prevents LSF from binding with HCC DNA, which results in HCC cell death.