Large-cell lymphoma
The large-cell lymphomas have large cells. One classification system for lymphomas divides the diseases according to the size of the white blood cells that have turned cancerous. A large cell, in this context, has a diameter of 17 to 20 μm. Other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas.
Types
B cell
is the most common of the large-cell lymphomas. MeSH now classifies the phrase "large-cell lymphoma" under "Diffuse large B cell lymphoma".Many other B-cell lymphomas feature large cells:
- Angiocentric lymphoma
- Burkitt's lymphoma
- Follicular large-cell lymphoma
- Immunoblastic lymphoma
- Intravascular large-cell lymphoma
- Primary mediastinal B-cell lymphoma
- T-cell–rich B-cell lymphoma
- Primary splenic lymphoma
- Primary central nervous system lymphomas, which are often diffuse large-B-cell lymphomas
- Richter's transformation: Diffuse Large B-cell Variant
- 1) ABC subtype
- 2) GCB subtype
This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously.
The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.