LSS
- Dock landing ship
- Epidemiology data for low-linear energy transfer radiation
- L. S. Sheshagiri Rao
- LSS (Last Song Syndrome)
- LSS (gene)
- LSS Data Systems
- Lakeland School System
- Langstaff Secondary School
- Large-scale structure of the universe
- Laurel Springs School
- Law Society of Saskatchewan
- Lawrence Sheriff School
- Lean Six Sigma
- Leicester Secular Society
- Licentiate of Sacred Theology
- Life Saving Society
- Lincoln Square Synagogue
- Lithic Studies Society
- Logistics Support System
- Lone Star Showdown
- Lone Star Steel Company
- Lumbar spinal stenosis
- Lunds Studentsångförening
- Space simulator
- XM26 Lightweight Shotgun System