LSL
- Engineered Lumber
- LSL (gene)
- LSL Property Services
- Landing Ship Logistics
- Larch Shared Language
- Laurent Lamothe
- Lead service line
- Leicestershire Senior League
- Leinster Senior League (association football)
- Leinster Senior League (cricket)
- Leinster Senior League (rugby union)
- Leisure Suit Larry
- Lesotho loti
- Liberty Shoes Limited
- Lincoln Savings and Loan Association
- Linden Scripting Language
- Locomotive Services Limited
- Logical shift left
- Long service leave
- Process Window Index