LSC
- Catalan Sign Language
- Colombia
- Colombian Sign Language
- Derrick
- LDAP
- LIGO Scientific Collaboration
- LStar Capital
- La Florida Airport (Chile)
- La Salle College
- Lafayette School Corporation
- Lake Superior College
- Landing Craft Assault
- Learning and Skills Council
- Legal Services Commission
- Legal Services Corporation
- Legend SuperCup
- Lichen simplex chronicus
- Lincoln Continental Mark VII
- Local School Councils
- Local Supercluster
- London School of Commerce
- London Society of Compositors
- London Symphony Chorus
- Lone Star Conference
- Luminescent solar concentrator
- Luzon Science Consortium
- Lyndon State College
- Message Sequence Chart
- NCAA Division II
- National Collegiate Athletic Association
- Shaped charge
- Sony Pictures
- USA Swimming
- Virgo Supercluster