LSB
- Lauryl tryptose broth
- Lavelle School for the Blind
- Least significant bit
- Least significant byte
- Legacy Standard Bible
- Legal Services Board
- Lenguaje de Señas Bolivianas
- Lexington State Bank
- Liga Sudamericana de Básquetbol
- Liga Superior de Baloncesto (Cuba)
- Linux Standard Base
- List of banks in Denmark
- Local Station Board
- Local services board (Ontario)
- London School Board
- Long spine board
- Low-surface-brightness galaxy
- Lower sideband
- Lutheran Service Book
- Luxembourg School of Business
- Lyceum of Subic Bay
- Lysergic acid 2-butyl amide
- Pacifica Radio