LPO
- LPO-50
- Lactoperoxidase
- Landing Page Optimization
- Law practice optimization
- Leading Petty Officer
- Legal Process Outsourcing
- Leningrad Philharmonic Orchestra
- Lexicographic path ordering
- Libertarian Party of Ohio
- Libration point orbit
- Limited principle of omniscience
- Lipid peroxidation
- London Philharmonic Orchestra
- Louisiana Philharmonic Orchestra
- Post Office