LIS
- Isotope separation
- Italian Sign Language
- LIS (programming language)
- Laboratory information system
- Land information system
- Language-independent specification
- Lateral internal sphincterotomy
- League and Self-Defense
- Legume Information System
- Levantine Sign Language
- Library and information science
- Lice (disambiguation)
- Life Is Strange (series)
- Life Is Strange (video game)
- Linear Integrated Systems
- Liquid-impregnated surface
- Lis (given name)
- Lis (linear algebra library)
- Lis (surname)
- Lis River
- Lis coat of arms
- Lis, Albania
- Lisbon Airport
- Liss (disambiguation)
- Lisse
- Lisses
- Lithium-sulphur battery
- Local information systems
- Location information server
- Locked-in syndrome
- London Interdisciplinary School
- Longest increasing subsequence
- Lyce
- Lys (disambiguation)
- Scottish Development International
- TRMM
- Tropical Rainfall Measuring Mission