L-Iso-LSD

l-Iso-LSD, also known as -iso-LSD or -iso-LSD, as well as l-isolysergic acid diethylamide, is a lysergamide and one of four possible stereoisomers of the lysergic acid diethylamide molecule.
The LSD molecule has two chiral centers at carbons 5 and 8 of the ergoline ring system and hence there are four possible enantiomeric stereoisomers of LSD. l-Iso-LSD, also known as -iso-LSD or -iso-LSD, is one of four possible stereoisomers. The other isomers are LSD -LSD, or, iso-LSD -iso-LSD, or, and l-LSD -LSD or. None of them are known to have significant psychoactivity in humans besides LSD.
l-Iso-LSD showed only 0.1% of the antiserotonergic activity of LSD in the isolated rat uterus. Hence, it was about 1,000-fold less potent than LSD in this assay and was regarded as essentially inactive.
l-Iso-LSD showed no psychedelic effects in humans at a dose of up to 500μg orally or up to 20times the minimum effective dose of LSD. According to Albert Hofmann, the only effect of l-iso-LSD at a dose of 500μg was mild nausea.
l-Iso-LSD was first described in the scientific literature by at least the 1950s.
File:Lysergide stereoisomers structural formulae v.1.png|thumb|left|400px|class=skin-invert-image|Chemical structures of LSD and its three stereoisomers, including l-iso-LSD.