KY 461begins at an interchange with KY 80southeast of Mark, within the central part of Pulaski County. It travels to the north-northwest and curves to the northeast. It crosses over Flat Lick Creek and then passes Bobbitt Cemetery. It intersects the western terminus of KY 1677. It then intersects the southern terminus of KY 3268 before traveling through Valley Oak. It crosses over Buck Creek and then crosses over Latham Branch twice. The highway curves to the north-northeast and intersects the eastern terminus of KY 934 before it enters Rockcastle County.
KY 461 has an intersection with both the western terminus of KY 1152 and the eastern terminus of KY 3273. It then curves to the northeast and crosses over Browne Fork and then the West Fork Skegg Creek. The highway curves to the north-northeast and intersects the southern terminus of KY 1250 and then the southern terminus of KY 2549. It curves to the northeast and intersecting U.S. Route 150. KY 461 then enters Mount Vernon. It intersects KY 1326. The highway temporarily leaves the city limits and curves to the east-northeast. When it re-enters the city, it meets its northern terminus, an intersection with US 25.