KY 390 travels along the county line and curves to the southeast. It crosses over Thompson Creek and enters Tablow. There, the highway intersects the western terminus of KY 926. The highway then enters Mercer County proper.
KY 390 enters Duncan, where it intersects the northern terminus of KY 1941. It continues to the southeast and intersects the eastern terminus of KY 1623. It travels through Bohon. It curves to the east-southeast and crosses over the Salt River. It curves to the southeast and crosses over some railroad tracks of Norfolk Southern Railway. The highway curves back to the east-southeast and enters Harrodsburg. It curves to the south-southeast and intersects the northern terminus of both Industry Road and Moberly Road. KY 390 turns left onto Industry Road, to the east-northeast, and leaves the city limits of Harrodsburg. It then curves to the east-southeast and meets its eastern terminus, an intersection with U.S. Route 127. Here, the roadway continues as US 127 Byp.