KY 272 begins at an intersection with U.S. [Route 68 in Kentucky|US 68]/KY 80 southwest of Cadiz, within Trigg County. It travels to the east and immediately intersects the northern terminus of KY 1062. It crosses over Caney [Creek (Kentucky)|Caney Creek] and curves to the southeast before curving to the northeast. It intersects the southern terminus of KY 1175. The highway intersects KY 139 and then crosses over Burge Creek. It begins curving to the southeast and crosses over Little River. KY 272 heads to the southeast and intersects the northern terminus of KY 1253. It curves to the east-southeast and intersects KY 1585. It crosses over Boyd Lake Branch and travels through Caledonia. The highway heads to the northeast and enters Christian County.