Karl Hoffmann

• Karl Hoffmann (architect), German architect
• Karl Hoffmann (politician), declined election to the Swiss Federal Council in 1881
• Karl Hoffmann (naturalist), German physician and naturalist
• Karl Hoffmann (linguist), German linguist
• Karl Hoffmann (rower), German Olympic rower
• Karl Hoffmann (footballer), German footballer
• Karl W. Hofmann, former United States Ambassador to Togo