The Dano-Norwegian settlement Sukkertoppen was originally located at the site of present-day Kangaamiut, when it was founded in 1755. It was moved to its present location at Maniitsoq in 1782.
Kangaamiut has experienced a sharp decline in its population. The settlement has lost more than 36% of its population relative to 1990 and more than 26% relative to 2000.