KLF14
Krüppel-like factor 14, also known as basic transcription element-binding protein 5 is a protein that in humans is encoded by the KLF14 gene. The corresponding Klf14 mouse gene is known as Sp6.
Function
KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII. KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression.KLF14 appears to be a master regulator of gene expression in adipose tissue.
Protein structure
Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124; in the mouse its length is 325.