He was ordained deacon in December 1969 and ordained priest the following year on 5 April 1970. In 1989 Alessandro went on a mission to Kenya where in 1994 he was shot and seriously injured whilst on his way to Garissa. Some years later he returned to Malta where he became the Provincial of the Capuchin Province of Malta. In Malta he also taught religion and lectured theology while serving on the diocesan film censorship board. In 2010 he returned to Kenya and was made Vicar General of the Diocese of Garissa by Bishop Paul Darmanin.