José Santiago

• José Santiago (1950s pitcher), Puerto Rican pitcher in Major League Baseball, 1954–1956
• José Santiago (1960s pitcher), Puerto Rican pitcher in Major League Baseball, 1963–1970
• José Santiago (2000s pitcher), Puerto Rican pitcher in Major League Baseball, 1997–2005
• José Avilés Santiago, Puerto Rican politician; mayor of Moca 2001–2021
• Jose L. Santiago, American politician
• José Luis Santiago Vasconcelos, Mexican civil servant killed in an aviation accident
• José Turiano Santiago, Filipino patriot in the 1896 Philippine Revolution